There are also several ongoing projects in the laboratory uncovering various mechanisms playing a role in the control of kidney function and the role of this vital organ in the control of blood pressure and various chronic kidney diseases.  For instance, recent studies revealed profound effects of Na+-glucose cotransporter-2 (SGLT2) inhibitors, which have become the new mainstay of treatment for diabetes mellitus and cardiovascular diseases. However, specific mechanisms of SGLT2i’s action are still a mystery.  Furthermore, the role of these inhibitors in non-diabetic settings is still unclear. In addition to the studies of SGLT2i, there are several other projects in the laboratory, focused on the role of opioid signaling, uric acid homeostasis, and reactive oxygen species, in kidney damage during the development of salt-induced hypertension. 

Representative publications:

https://pubmed.ncbi.nlm.nih.gov/35466690/

https://pubmed.ncbi.nlm.nih.gov/33046522/

https://pubmed.ncbi.nlm.nih.gov/32799394/